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Abstract
BackgroundThe Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) module four assessment for diagnosing autism spectrum disorder in adults has shown good sensitivity and specificity in research settings.MethodThis study aimed to evaluate the predictive accuracy of the ADOS-2 module four by investigating the components of the assessment, in relation to diagnostic outcome in a clinical setting. Data from 88 service users referred to a Specialist Adult Autism Service was explored.ResultsADOS-2 scores failed to predict the diagnostic outcome (overall sensitivity = 92%, specificity = 57%). Interestingly, scores from the ‘restricted interests’ component of the ADOS-2 have the potential to predict diagnostic outcome, despite this domain not been included in the scoring algorithm.ConclusionsBased on our findings, we recommend clinicians are cautious when interpreting results of the ADOS-2 assessment.
Highlights
The Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) module four assessment for diagnosing autism spectrum disorder in adults has shown good sensitivity and specificity in research settings
Employing The autism diagnostic observation schedule (ADOS)-2 scores as independent variables, we explored the predictive value of the outcome variable, which was subsequent confirmed diagnosis of Autism spectrum disorder (ASD) based on expert clinical judgements
Whilst we found that those patients who went on to receive a diagnosis scored greater overall, our interest here was the predictive efficacy of the scores of the individual The autism diagnostic observation schedule (ADOS-2) domains, in relation to final diagnostic formulation by an expert multidisciplinary team, in a sample of adults referred to a specialist Service for possible ASD
Summary
The Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) module four assessment for diagnosing autism spectrum disorder in adults has shown good sensitivity and specificity in research settings. Method: This study aimed to evaluate the predictive accuracy of the ADOS-2 module four by investigating the components of the assessment, in relation to diagnostic outcome in a clinical setting. Data from 88 service users referred to a Specialist Adult Autism Service was explored. Results: ADOS-2 scores failed to predict the diagnostic outcome (overall sensitivity = 92%, specificity = 57%). Scores from the ‘restricted interests’ component of the ADOS-2 have the potential to predict diagnostic outcome, despite this domain not been included in the scoring algorithm. Conclusions: Based on our findings, we recommend clinicians are cautious when interpreting results of the ADOS2 assessment
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