Predicting decay in free-radical concentration in L-α-alanine following high-LET radiation exposures

Abstract

Efforts have been made to develop a model that will predict time-dependent decay in radiation-induced free-radical concentration in L-α-alanine following heavy-charged-particle exposures. The decay rate depends on radiation quality, dose and dose-rate. For low doses, the decay-rate is approx. 0.5 and 1.5% per year following 60Co λ-ray exposures and Linac-produced x-ray or electron exposures. Decay rates, however, have been found to increase as measured from low average doses, sparse single tracks, of heavy charged particles. We have compared measured decay after exposures to low average doses from high-LET particles with predicted decay calculated as function of particle velocity and charge and detector parameters. The predicted decay is obtained by folding measured decay after Linac-produced electron exposures of very high doses into the calculated dose distribution around the heavy ion's path. Preliminary results show agreement between the experimental data and results obtained from this model, within the experimental uncertainty.