Abstract
The solubility ratio of organic chemicals in an organic solvent and in water, σ, has been found to correlate with the logarithm of the octanol−water partition coefficient (log Kow) of the solutes; i.e., log σ = N + M log Kow. A total of 607 sets of thousands of solubility data were extracted from literature sources. From this database, values of N and M are obtained for 15 completely water-miscible cosolvents which are often used in pharmaceutical and environmental activities. A linear free energy relationship between σ and log Kow is theoretically derived. The deviation of the slope M from the theoretical value of unity seems to originate mainly from the differences in activity coefficients of solute in water-saturated octanol and in pure cosolvent. The effect of dissolved octanol in water in defining Kow may also influence the slope of σ ∼ log Kow regression.
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