Abstract

Attention deficit hyperactivity disorder (ADHD) is one of childhood’s most frequent neurobehavioral disorders. The purpose of this study is to: (i) extract the most prominent risk factors for children with ADHD; and (ii) propose a machine learning (ML)-based approach to classify children as either having ADHD or healthy. We extracted the data of 45,779 children aged 3–17 years from the 2018–2019 National Survey of Children’s Health (NSCH, 2018–2019). About 5218 (11.4%) of children were ADHD, and the rest of the children were healthy. Since the class label is highly imbalanced, we adopted a combination of oversampling and undersampling approaches to make a balanced class label. We adopted logistic regression (LR) to extract the significant factors for children with ADHD based on p-values (<0.05). Eight ML-based classifiers such as random forest (RF), Naïve Bayes (NB), decision tree (DT), XGBoost, k-nearest neighborhood (KNN), multilayer perceptron (MLP), support vector machine (SVM), and 1-dimensional convolution neural network (1D CNN) were adopted for the prediction of children with ADHD. The average age of the children with ADHD was 12.4 ± 3.4 years. Our findings showed that RF-based classifier provided the highest classification accuracy of 85.5%, sensitivity of 84.4%, specificity of 86.4%, and an AUC of 0.94. This study illustrated that LR with RF-based system could provide excellent accuracy for classifying and predicting children with ADHD. This system will be helpful for early detection and diagnosis of ADHD.

Highlights

  • Attention deficit hyperactivity disorder (ADHD) is one of the most frequent neurodevelopmental behavioral disorders in childhood [1]

  • According to the Centers for Disease Control (CDC) and prevention, the number of children in the USA who have been diagnosed with ADHD has fluctuated over time as follows: about 4.4 million children between the ages of 2 and 17 years were diagnosed with ADHD in 2003, 5.4 million children in 2007, 6.4 million children in 2011, and 6.1 million children in 2016 [2]

  • The age range included in our analysis was from 3–17 years, with the average age of the children being 10.6 ± 4.4 years, with an ADHD disease age of 12.4 ± 3.4 years

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Summary

Introduction

Attention deficit hyperactivity disorder (ADHD) is one of the most frequent neurodevelopmental behavioral disorders in childhood [1]. Children with ADHD have the following symptoms: hyperactivity, inattention, and impulsivity [1]. According to the Centers for Disease Control (CDC) and prevention, the number of children in the USA who have been diagnosed with ADHD has fluctuated over time as follows: about 4.4 million children between the ages of 2 and 17 years were diagnosed with ADHD in 2003, 5.4 million children in 2007, 6.4 million children in 2011, and 6.1 million children in 2016 [2]. About 12.9% of male children and 5.6% of females were diagnosed with ADHD [2,3]. There were 62% of children who had taken medication for ADHD, and 46.7% of those children had received behavioral treatment [2]. It is noted that the number of children with ADHD has been increasing day by day. It is necessary to propose a model for the identification of the risk factors for ADHD

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