Abstract
9001 Background: Older adults are vulnerable to chemotherapy (chemo) toxicity (tox); however, there is limited data to identify those at risk. The goals of this study are to: 1) identify risk factors for grade 3-5 chemo tox in older adults and 2) develop a risk-stratification schema for grade 3-5 tox based on the number of risk factors. Methods: Patients age ≥ 65 with cancer from 7 institutions completed a pre- chemo assessment capturing: 1) sociodemographics, 2) tumor/treatment variables, 3) labs, 4) Karnofsky performance status, and 5) geriatric assessment [functional, psychological, and nutritional status, comorbidity, cognition, and social activity/support (Hurria et al, Cancer 2005)]. Patients were followed through the chemo course to capture grade 3-5 tox. Multivariate logistic regression was used to identify independent risk factors for grade 3-5 tox. Results: 500 patients [mean age 73 (range 65-91)] with cancer [lung (29%), breast/gyn (28%), GI (27%), GU (10%), or other (6%)] participated (61% had...
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