Abstract
Genomic variants with a key role in causing cancer or affecting the response to cancer therapeutics need to be identified so that they can be targeted for therapy. The transFIC tool aims to identify somatic point mutations that drive cancer in sequencing projects. This package is available as a web service, a stand-alone program and a website. It improves the functional prediction scores generated by popular established prediction tools and will be useful to cancer researchers.See research article: http://genomemedicine.com/content/4/11/89
Highlights
Genomic variants with a key role in causing cancer or affecting the response to cancer therapeutics need to be identified so that they can be targeted for therapy
In a metastatic colorectal cancer study, it was reported that none of the patients with BRAF mutations responded to treatment with the drugs panitumumab or cetuximab [2]. us, activating somatic mutations can affect drug sensitivities
Sifting through these somatic single nucleotide variants (SNVs) to pin down the few driver mutations implicated in cancer is a challenge
Summary
Genomic variants with a key role in causing cancer or affecting the response to cancer therapeutics need to be identified so that they can be targeted for therapy. Identifying driver and passenger mutations When sequencing a cancer genome, somatic single base substitutions can number in the tens of thousands [3].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
