Predicting Blood Oxygenation Level-Dependent Activity in Fusiform Face Area from the Activity in Other Visual Areas.

Abstract

Neuroimaging studies have shown that discrete regions in ventral visual pathway respond selectively to specific object categories. For example, the fusiform face area (FFA) in humans is consistently more responsive to face than nonface images. However, it is not clear how other cortical regions contribute to this preferential response in FFA. To address this question, we performed a functional magnetic resonance imaging study on human subjects watching naturalistic movie clips from human actions. We then used correlation and multivariate regression (partial least-squares regression) analyses to estimate/predict the mean BOLD (blood oxygenation level-dependent) activity in FFA, from the mean and pattern of responses in 24 visual cortical areas. Higher tier retinotopic areas V3, hV4, and LO2, motion-selective area middle temporal, body-selective areas, and non-FFA face-selective areas had the best prediction accuracy particularly when they were located ipsilateral to FFA. All non-FFA collectively could explain up to 75% of variance in the FFA response. The regression models were also designed to predict the mean activity in one face area from the pattern of activity in another face area. The prediction power was significantly higher between the occipital face area and FFA. The multivariate regression analysis provides a new framework for investigating functional connectivity between cortical areas, and it could inform hierarchical models of visual cortex.