Abstract
Blood glucose is conventionally determined by the level of sugar present in our blood. Lesser known to the public that antioxidants in our body are also said to influence the level of blood glucose. Glutathione (GSH) as the main antioxidant parameter in our body helps in reducing the production of oxidative stress caused by a high blood glucose level. Particularly in women, high antioxidant activities are reported due to the presence of oestrogen hormone. However, in Malaysia limited study was done on the significance of GSH in influencing the blood glucose level. Thus, this study focuses on finding the significance of GSH and some other health predictors in affecting the blood glucose level of women volunteers. This study was carried out on 118 Malaysian women volunteers and blood samples were collected for GSH analysis and blood glucose. All data were trained and tested for the development of prediction models in classifying the blood glucose into normal and abnormal levels. The model construction is using three different classifiers: namely logistic regression, k-nearest neighbour classifier and decision tree. Five predictors that were used are GSH, weight, body mass index (BMI), waist-hip ratio (WHR) and groups (oral supplementation dosage). Results showed all predictors are significantly correlated with the blood glucose level at p < 0.10. The model with a combination of GSH, BMI, WHR, weight and supplementation dosage (groups) as predictors gave the best performance. The k-nearest neighbour classifier model displays the best accuracy (84.7%) in predicting the normal and abnormal level of blood glucose. This finding shows that by altering the amount of GSH via oral supplementation and other significant predictors in women, there are chances to modify the blood glucose level from abnormal to normal
Highlights
Having high blood sugar or glucose level pinpoint as one of the silent killers in the Malaysian population
This study has successfully developed models to predict the blood glucose level
The prediction models are based on GSH, body mass index (BMI), waist to hip ratio (WHR), weight and supplementation dosage parameters
Summary
Having high blood sugar or glucose level pinpoint as one of the silent killers in the Malaysian population. A report by Ministry of Health (MOH) Malaysia, according to the National Health and Morbidity Survey [NHMS] (2020), the widespread rate of diabetes in adults has increased in Malaysia from 13.4% in 2015 to 18.3% in 2019, with diabetes defined as having sugar levels 7.0 μmol L-1 or above. Unknown, antioxidants or glutathione (GSH) in our body is important to inactivate reactive oxygen species (ROS) which cause many chronic diseases such diabetes. Excess glucose in blood causes enhancement of free radicals production by increasing the oxidant status and decreasing the antioxidant capacity exerted by glutathione mechanism in the body (Avelar et al, 2015, Ceriello & Motz, 2004)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
