Abstract

Predicting bladder cancer responses to PD-L1 inhibitors? A case report and overview for the busy clinician

Highlights

  • Case ReportPredicting bladder cancer responses to PD-L1 inhibitors?

  • Bladder cancer is the sixth most common form of cancer in the United States and ranks fourth among men. 81,190 new cases of bladder cancer and 17,240 deaths attributable to bladder cancer are predicted to occur in 2018 in the United States alone [1]

  • As of the beginning of this year, there have been five therapies targeting the PD-1/ PD-L1 axis approved for second-line treatment of metastatic urothelial cancer with two approved for first-line therapy in cisplatin-ineligible patients (Tables 1 and 2)

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Summary

Case Report

Predicting bladder cancer responses to PD-L1 inhibitors? A case report and overview for the busy clinician. Seranio N, Malkowicz SB, Aguarin L, Dorsey JF, Christodouleas J and Kao GD* Departments of Radiation Oncology and Urology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

Introduction
Predictors of response
TCGA Subtyping
Mutational burden
TCGA subtyping
Predictors of resistance
Predictors of hyperprogression
Case report
Findings
Conclusion
Full Text
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