Predict lymph node status according to the solid size and maximum standardized uptake value of lung adenocarcinoma with a size of ≤3 cm

Abstract

Objective To analyze the value of predict lymph node status according to the tumor size, solid size, and maximum standardized uptake value(SUVmax) in adenocarcinoma of the lung with a size of ≤3 cm. Methods One hundred and thirty-six patients who had undergone curative resection for lung adenocarcinoma were enrolled in this retrospective study.The largest transverse sectional diameter of the tumor and solid size were measured. Then SUVmax of the main tumor was assessed. Logistic regression analysis was performed by taking the lymph node status as the dependent variable,and the size of solid component of tumor, SUVmax were taken as independent variables. The predicted probability of the Logistic regression model was enrolled in receiver operating characteristic analysis. Results Among the 136 cases of lung adenocarcinoma, the incidence of lymph node metastasis was 24.3% (33/136). Logistic regression analysis showed that the size of the solid component (OR 3.880, 95% CI 1.788 to 8.421, P 0.05). The ROC curve analysis was performed based on the predicted probability of Logistic regression model, and the area under the curve was 0.838(P<0.01) Conclusions Solid size and SUVmax are important predictors for lymph node metastasis of lung adenocarcinoma with a size of ≤3 cm, and it may be helpful to avoid unnecessary limited resection or lymph node dissection. Key words: Lung neoplasms; Adenocarcinoma; Lymphatic metastasis