Abstract
No study to date has prospectively evaluated the association between pre-diagnostic cruciferous vegetables intake and lung cancer survival among women. This analysis included 547 incident lung cancer cases identified from the Shanghai Women’s Health Study (SWHS) during the follow-up period of 1997-2011. Dietary intake was assessed for all SWHS participants at enrollment and reassessed 2-3 years later. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) with adjustment for potential confounders. Of the 547 lung cancer patients, 412 patients died during the follow-up. A total of 393 (95.4%) deaths from lung cancer were documented with median survival time of 10.3 months (interquartile range, 3.6-21.1 months). High cruciferous vegetables intake was significantly associated with improved lung cancer-specific survival after adjusting for all nonclinical prognostic factors (n = 547, HR = 0.69; 95%CI = 0.49-0.95; P trend = 0.02) for the highest versus lowest quartile. A slightly stronger association of cruciferous vegetables intake with lung cancer-specific survival was observed in analyses restricted to patients with known clinical prognostic factors (n = 331, HR = 0.63; 95%CI = 0.41-0.97; P trend = 0.03) or never smokers (n = 308, HR = 0.58; 95%CI = 0.37-0.91; P trend = 0.02). In conclusion, pre-diagnostic cruciferous vegetables intake is associated with better survival of lung cancer in Chinese women.
Highlights
Our recent study from the Shanghai Women’s Health Study (SWHS) demonstrated that cruciferous vegetables intake significantly decreased 41% incident lung cancer risk among female nonsmokers[14]
Several meta-analyses have confirmed the protective role of cruciferous vegetables intake in lung cancer risk[14,15], no study to date has focused on the association between pre-diagnostic cruciferous vegetables intake and the lung cancer survival
In this report, we prospectively investigate the hypothesis that women with lung cancer with higher pre-diagnostic cruciferous vegetables may have better prognosis
Summary
Our recent study from the Shanghai Women’s Health Study (SWHS) demonstrated that cruciferous vegetables intake significantly decreased 41% incident lung cancer risk among female nonsmokers[14]. Several meta-analyses have confirmed the protective role of cruciferous vegetables intake in lung cancer risk[14,15], no study to date has focused on the association between pre-diagnostic cruciferous vegetables intake and the lung cancer survival. In this report, we prospectively investigate the hypothesis that women with lung cancer with higher pre-diagnostic cruciferous vegetables may have better prognosis
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