Prediabetes is not a risk factor for subclinical coronary atherosclerosis

Abstract

BackgroundThere are limited data regarding the influence of glycemic status on the risk of subclinical coronary atherosclerosis on coronary computed tomographic angiography (CCTA) in asymptomatic individuals. MethodsWe analyzed 6434 asymptomatic individuals who underwent CCTA. The degree and extent of subclinical coronary atherosclerosis were assessed by CCTA, and ≥50% diameter stenosis was defined as significant. Of study participants, 2197 (34.1%), 3122 (48.5%), and 1115 (17.3%) were categorized as normal, prediabetic and diabetic individuals, respectively. ResultsCompared with normal individuals, there were no statistically differences in the adjusted odds ratios of prediabetic individuals for significant coronary artery stenosis (0.98, 95% confidence interval [CI] 0.80–1.22, p=0.888), any plaque (0.96, 95% CI 0.86–1.07, p=0.483), calcified plaque (0.90, 95% CI 0.79–1.01, p=0.080), non-calcified plaque (1.02, 95% CI 0.88–1.17, p=0.803), and mixed plaque (1.00, 95% CI 0.82–1.22, p=0.983). However, adjusted odds ratios for significant coronary artery stenosis (1.71, 95% CI 1.34–2.19, p<0.001), any plaque (1.45, 95% CI 1.26–1.68, p<0.001), calcified plaque (1.35, 95% CI 1.15–1.57, p<0.001), non-calcified plaque (1.33, 95% CI 1.11–1.59, p=0.002), and mixed plaque (1.64, 95% CI 1.30–2.07, p<0.001) of diabetic individuals were significantly higher than those of the normal individuals. ConclusionIn asymptomatic individuals, diabetic individuals had a higher risk for subclinical coronary atherosclerosis, but prediabetic individuals were not associated with an increased risk of subclinical coronary atherosclerosis.