Abstract
In a recently published paper in Cardiovascular Diabetology, Sinha et al. (Association of fasting glucose with lifetime risk of incident heart failure: the Lifetime Risk Pooling Project. Cardiovasc Diabetol. 2021;20(1):66) reported that prediabetes (defined as a fasting plasma glucose concentration of 100–125 mg/dL) was associated with a higher lifetime risk of heart failure in middle-aged White adults and Black women, with the association attenuating in older Black women. This study provides important evidence that the risk of heart failure is increased in people with a fasting plasma glucose concentration as low as 100 mg/dL, supporting the definition of prediabetes according to the American Diabetes Association guideline. The study also strongly supports the notion that prediabetes should be regarded not only as a high-risk state for the development of diabetes but also as a risk factor for cardiovascular morbidity.
Highlights
impaired fasting glucose (IFG) is defined as an elevated fasting glucose concentration, and impaired glucose tolerance (IGT) is defined as a high 2-h plasma glucose concentration during an oral glucose tolerance test that does not reach the diagnostic cut-off point for diabetes
The cut-off points for diagnosing prediabetes using the fasting plasma glucose (FPG) and Hemoglobin A1c (HbA1c) concentrations remain controversial
The counterargument is that the definition of prediabetes proposed by the American Diabetes Association (ADA) guideline significantly increases the prevalence of blood glucose dysregulation with no clear association with diabetic complications
Summary
In a recently published paper in Cardiovascular Diabetology, Sinha et al Prediabetes, termed “intermediate hyperglycemia,” is an intermediate metabolic state between type 2 diabetes mellitus (T2DM) and normoglycemia and includes patients with impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) [1, 2]. IFG is defined as an elevated fasting glucose concentration, and IGT is defined as a high 2-h plasma glucose concentration during an oral glucose tolerance test that does not reach the diagnostic cut-off point for diabetes.
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