Abstract
5-Hydroxytrypotophan at a dose of 50 mg/kg intraperitoneally (i.p.) sharply increased neural serotonin (5-HT) levels in mink and considerably inhibited that animal's predatory attack on rats. Intraperitoneal injection of 5-HT (10 and 20 mg/kg) did not influence such rat-killing. Neural levels of 5-HT or 5-hydroxyindoleacetic acid (5-HIAA) and subsequent aggression by the predator did not change to any great degree after ingestion of a single meal. Abundance of natural mink food for 3 days was associated with an increased level of 5-HIAA in the lateral hypothalamus and the amygdala as well as with an increased latency to attack and to kill rats. 5-HT seems to represent an endogenous factor that inhibits predatory attack by the mink; this effect appears to function through increased metabolism of 5-HT in some brain regions, which is evident after abundant intake of tryptophan with the natural diet.
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