Abstract
The electrochemical oxidation and detection of indomethacin in phosphate buffer (pH 7) at carbon paste electrodes is described. The response is characterized with respect to paste composition, preconcentration time, accumulation potential, indomethacin concentration, stirring effect, reproducibility and other variables. Two mechanisms of accumulation are differentiated: an adsorptive accumulation of the analyte at the graphite particles of the Nujol or silicone oil electrodes and extractive accumulation into the castor-oil based electrode. The preconcentration/medium-exchange approach was exploited for selective determination of indomethacin in urine sample at the castor oil electrode. A detection limit of 2.5 × 10−8 M was obtained for a dilute urine sample after 20 min accumulation and a medium-exchange procedure.
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