Abstract

BackgroundToy slime is popular in Korea, and in parallel, pre-pubertal girls visit hospitals for early pubertal signs. Thus far, numerous studies have investigated the association of endocrine-disrupting chemicals (EDCs) with precocious puberty (PP). However, there is a lack of studies on the clinical manifestations and sex hormones. We aimed to investigate early pubertal development in Korean girls with or without a history of toy slime exposure and determine changes in bone age, Tanner stage, and sex hormones.MethodsIn this study, 140 girls underwent stimulation tests at Kyungpook National University Children’s Hospital Endocrinology Department, during January 2018 and December 2020. Patients were divided into two groups for gonadotropin-releasing hormone (GnRH) stimulation test and frequency of exposure to toy slime (EDCs). GnRH stimulation test was conducted after an intravenous injection of 100 µg of luteinizing hormone-releasing hormone. Slime exposure was defined as Slime ≥ 3 times/week for ≥ 3 months.ResultsHistory of slime exposure was found in 14 of 58 and 65 of 82 patients in the central PP (CPP) and non-CPP groups, respectively. Slime-exposed patients had advanced bone age, although their Tanner stage was low. Patients with a history of toy slime exposure were 5.5 times more likely to be diagnosed with non-CPP than patients without slime exposure (p < 0.05).ConclusionsExposure to toy slime in prepubertal girls may be associated with rapid clinical advancement of pubertal development and bone age, and the patients appear more likely to be diagnosed with non-CPP.

Highlights

  • Toy slime is popular in Korea, and in parallel, pre-pubertal girls visit hospitals for early pubertal signs

  • bone age (BA), BA chronological age (CA), body mass index (BMI; z-score), Tanner stage, basal luteinizing hormone (LH) level, folliclestimulating hormone (FSH) level, DHEA-s level, and gonadotropin-releasing hormone (GnRH) stimulation test results were retrospectively analyzed for each subject

  • The two groups showed no significant differences in CA or BA-CA and height SDS

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Summary

Introduction

Toy slime is popular in Korea, and in parallel, pre-pubertal girls visit hospitals for early pubertal signs. We aimed to investigate early pubertal development in Korean girls with or without a history of toy slime exposure and determine changes in bone age, Tanner stage, and sex hormones. Precocious puberty (PP) in girls is defined as a condition wherein the first pubertal sign occurs before the age of 8 years [1]. It is categorized into central PP (CPP), peripheral PP (PPP), and benign pubertal variants. This study investigated the history of toy slime exposure (history of exposure to EDCs) in patients who visited the hospital due to early pubertal development. This study determined the changes in bone age (BA), Tanner stage, and sex hormones including GnRH stimulation test results

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