Abstract
A preclinical safety study of an antimicrobial phyto preparation «Sanguiritrin» in immature animals was carried out. It is shown that at a single intraperitoneal administration of«Sanguiritrin» to newborn baby rats and rats of 3 weeks of age, a mean lethal dose was set at a level of 22.0 ± 2.5 mg/kg and 17.6 ± 1.5 mg/kg (male), 18.0 ± 2,0 mg/kg (female), respectively. Infant rats are less sensitive to the «Sanguiritrin» toxic effect as compared to sexually mature rats (LD50 10.0-12.0 mg/kg). A long-term peroral administration (2 months) of the substance «Sanguiritrin» in a dose of 0.5 mg/kg did not have a damaging effect on 3 weeks of age rats major body organs and systems. The intake of «Sanguiritrin» in infant rats in a dose of 5 mg/kg significantly decreased their body weight and disturbed renal excretory function. Application of 0.2% alcohol solution and 1% liniment «Sanguiritrin» to the skin of newborn baby rats and 3 weeks of age rats under conditions of a chronic experiment showed a good tolerability, absence of local irritating action and undesirable toxic effects.
Highlights
В настоящее время 0,2% спиртовой раствор и 1% линимент «Сангвиритрина» разрешены к медицинскому применению у детей, в том числе у новорожденных
Krepkova L.V., Bortnikova V.V. Preclinical studying of safety of an antimicrobic preparation с Sangviritrin // Voprosy biologicheskoi, meditsinskoi i farmatsevticheskoi khimii
Summary
Примечание:* – здесь и в последующих таблицах достоверность различий с контролем (*Р
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