Abstract
Focused ultrasound with microbubbles (FUS-MBs) has shown that it can lead to an efficient drug delivery system (DDS) involving the oscillation and destruction of the MB but is limited in drug delivery due to its narrow pressure field. However, unfocused ultrasound with MBs (UUS-MBs) and an interchangeable acoustic lens can tune and enhance the pressure field for MB destruction to overcome the disadvantages of FUS-MB DDSs. We designed a lens suitable for an ultrasound-phased array probe and studied the optimal treatment conditions for MB destruction in vitro through an optical imaging setup. The DDS effects were evaluated in a rat hepatoma model using doxorubicin (DOX) treatment. A concave lens with a radius of curvature of 2.6 mm and a thickness of 4 mm was selected and fabricated. UUS-MBs with the acoustic lens at 60 Vpp for 32 cycles and a PRF of 1 kHz could induce MB destruction, promoting the DDS even under fluidic conditions. In the animal experiment, the UUS-MBs in the acoustic lens treatment group had a higher concentration of DOX in the tumor than the control group. Our system suggests uses an acoustic lens to increase DDS effectiveness by providing sufficient ultrasound irradiation to the MBs.
Highlights
Focused ultrasound with microbubbles (FUS-MBs) has shown that it can lead to an efficient drug delivery system (DDS) involving the oscillation and destruction of the MB but is limited in drug delivery due to its narrow pressure field
Focused ultrasound with microbubbles (FUS-MBs), which are commonly used in clinical practice due to their proven safety, have shown highly efficient therapeutic effects with complex phenomena that involve the oscillation and destruction of M Bs10,11
Previous studies have been employed to address these limitations via unfocused ultrasound with MBs (UUSMBs), and the effectiveness of UUS-MBs has been demonstrated
Summary
Focused ultrasound with microbubbles (FUS-MBs) has shown that it can lead to an efficient drug delivery system (DDS) involving the oscillation and destruction of the MB but is limited in drug delivery due to its narrow pressure field. Recent research has shown improvements in cancer drug delivery to malignant tumors with FUS-MBs12,13 Despite these promising results, fixed-focused ultrasound with a narrow pressure field might limit accurate drug delivery by aligning blood vessels to the lesion due to the vascular. We hypothesized that ultrasound with an acoustic lens might produce an efficient strategy for safe extensive drug delivery to the target lesion without damaging other normal tissues, giving a cost-effective and straightforward solution
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