Preclinical studies of testicular ischemia-reperfusion treatment

Abstract

Testicular torsion occurs annually in appr. 3.8/100.000 under the age of 18 years The condition has a bimodal incidence pattern with peaks in infancy and early adolescence [ [1] Zhao L.C. Lautz T.B. Meeks J.J. Maizels M. Pediatric testicular torsion epidemiology using a national database: incidence, risk of orchiectomy and possible measures toward improving of care. J Urol. 2011; 186: 2009-2013 Crossref PubMed Scopus (150) Google Scholar ]. If retorsion is performed within the first few hours, there might be a chance of preservation of testicular function, but when the time period from onset of symptoms exceeds 12 h, the testicular function is lost. So acute surgery is mandatory, but could it be possible to get a higher success rate with supplementary measures? This is the topic of the preclinical study by [ [2] Tanriverdi H.I. Senel U. Gevrek F. Akbas A. Protective effect of famotidine on ischemia-reperfusion injury following testicular torsion in rats. J Pediatr Urol. 2021; 17: 167 Abstract Full Text Full Text PDF PubMed Scopus (7) Google Scholar ] where they explore the effect of famotidine, a competitive inhibitor of histamine H2 receptors, normally used to reduce gastric acid, to counteract the reperfusion damages to the testicular tissue? Protective effect of famotidine on ischemia–reperfusion injury following testicular torsion in ratsJournal of Pediatric UrologyVol. 17Issue 2PreviewIn testicular torsion, testicular blood flow is impaired, resulting in ischemic changes. Torsion must be corrected urgently with surgical treatment. Detorsioning and restoration of blood supply to the testis cause reperfusion injury. Full-Text PDF