Abstract
Diarrhea is a global epidemic mostly common in developing countries, especially among children below five years. The side effects posed by conventional antidiarrheal agents necessitate the screening and development of alternative agents. This review assessed the current experimental techniques involved in screening agents with promising anti-diarrheal properties. The various models described include; in-vivo model (gastrointestinal transit time using charcoal meal, Castor oil-induced diarrhea, Castor oil-induced enteropooling, Magnesium sulfate induced diarrhea, Prostaglandin (PGE2) induced enteropooling and Serotonin induced diarrhea), intestinal enteroids model (enterotoxigenic escherichia coli -induced diarrhea, enteropathogenic escherichia coli induced diarrhea and cholera toxin-induced diarrhea) as well as ex - vivo model (involving the use of isolated jejunum or ileum from guinea pigs, rabbits and rats). Innovative screening areas covered include; enkephalinase, intestinal ion channels and inflammatory bowel disease (IBD) associated diarrhea and Farnesoid X Receptor (FXR) target. Advantages and disadvantages of these techniques were also highlighted. Application of these models would aid in the discovery of alternative antidiarrheal agents.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: American Journal of Physiology, Biochemistry and Pharmacology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
