Abstract
Objective: The main goal of our study was to investigate the antidepressant activity of Formulated Sertraline hydrochloride-loaded Solid Lipid Nanoparticles (SLNPs) by using a rat forced swimming test (FST) and tail suspension test (TST).
 Materials and Methods: Animals were divided into three groups, consisting of six rats in each group. Out of these, one group served as control that received distilled water, second group was standard received Sertraline HCl (20 mg/kg intranasal) and third group was received test formulation (SLNPs 50 mg/kg intranasal). To assess the effect of SLNPs on immobility activity through FST and TST were used to take as a measure of antidepressant activity.
 Results: SLNPs reduced the immobility duration in TST as well as in FST. In both methods, there was a statistical significant decrease in immobility of SLNPs group when compared to the control group.
 Conclusion: The results suggested that SLNPs produced significant antidepressant effect in rats which was comparable with control group and standard Sertraline HCl group animals.
Highlights
IntroductionDepression is a life-threatening psychiatric disorder and a major public health concern worldwide with an incidence of 5% and lifetime prevalence of 15-20%
Group I: Group control given Distilled water.Depression is a life-threatening psychiatric disorder and a major public health concern worldwide with an incidence of 5% and lifetime prevalence of 15-20%
There was a statistically significant (P
Summary
Depression is a life-threatening psychiatric disorder and a major public health concern worldwide with an incidence of 5% and lifetime prevalence of 15-20%. Depression is associated with disability, decreased quality of life, increased health-related costs and is considered main risk factor for many diseases, including cardiovascular, metabolic and neuropsychiatric disorders [3,4]. Current pharmaco-therapeutic treatments have limited efficacy and are associated with many deleterious side effects [5,6]. Animal models are essential for advance research in this field. In this view, the present study was designed to preclinical screening the ability of SLNPs as antidepressants in rats
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