Preclinical Model of Optical Coherence Tomography for High-Resolution Deep-Brain Imaging for Laser Ablation.

Abstract

HomeRadiology: Imaging CancerVol. 2, No. 3 PreviousNext Research HighlightsFree AccessPreclinical Model of Optical Coherence Tomography for High-Resolution Deep-Brain Imaging for Laser AblationAdeline N. BoettcherAdeline N. BoettcherAdeline N. BoettcherPublished Online:May 29 2020https://doi.org/10.1148/rycan.2020204016MoreSectionsPDF ToolsImage ViewerAdd to favoritesCiteTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinked InEmail Take-Away Points■ Major Focus: Preclinical in vivo imaging of the deep brain using an optical coherence tomography (OCT) needle for tissue visualization and laser ablation.■ Key Result: OCT imaging in a murine model was capable of producing high-resolution images of the deep brain before and after laser ablation at a resolution of 1.7 μm (axial) × 5.7 μm (lateral).■ Impact: Development of this tool for deep-brain imaging and ablation would allow for more precise and real-time imaging during ablation procedures in clinical practice.High-resolution three-dimensional imaging would be beneficial for viewing solid organs for planning and monitoring of cancer ablation therapies. Typical laser ablation procedures require MRI to determine where the target lesion is located, to confirm placement of the ablation probe, and to observe the effect of ablation during the procedure. For sensitive imaging areas, such as the brain, time needed for MRI to verify probe positioning and possible repositioning increases risk of injury to the patient. Together, a real-time high-resolution imaging technique that could overcome these issues would be beneficial for planning and monitoring of solid organ ablation procedures.In this study, Yuan et al assembled an 800-nm optical coherence tomography (OCT) imaging needle that was capable of high-resolution imaging (1.7 μm [axial] × 5.7 μm [lateral]). Additionally, this needle was equipped with a near-infrared laser for tissue ablation. For their first proof-of-concept study, the group imaged brain tissue in mice by introducing the microneedle through two burr holes made in the skull. Three-dimensional, color-coded images were generated by imaging a 4.5-mm-long cylindrical volume in the deep brain. Images detected even filament bundles in deep brain tissues. The authors also successfully imaged brain tumors marked with green fluorescent protein. Images from both normal and malignant brain tissue showed high concordance to histology.To demonstrate potential imaging laser ablation procedures in patients, the authors imaged mouse brains before and immediately after laser ablation. By assessing volumetric OCT brain images, the authors verified successful laser ablation of the target volume demonstrated by histology. Taken together, the authors show exciting first steps toward developing an OCT microneedle for real-time high-resolution clinical imaging and precision laser ablation of solid organ tumors, such as glioblastomas.Highlighted ArticleYuan W, Chen D, Sarabia-Estrada R, et al. Theranostic OCT microneedle for fast ultrahigh-resolution deep-brain imaging and efficient laser ablation in vivo. Sci Adv 2020;6(15):eaaz9664. doi: 10.1126/sciadv.aaz9664Highlighted ArticleYuan W, Chen D, Sarabia-Estrada R, et al. Theranostic OCT microneedle for fast ultrahigh-resolution deep-brain imaging and efficient laser ablation in vivo. Sci Adv 2020;6(15):eaaz9664. doi: 10.1126/sciadv.aaz9664 Crossref, Medline, Google ScholarArticle HistoryPublished online: May 29 2020 FiguresReferencesRelatedDetailsRecommended Articles Image-guided Microinvasive Percutaneous Treatment of Breast Lesions: Where Do We Stand?RadioGraphics2021Volume: 41Issue: 4pp. 945-966Effects of a Thermal Accelerant Gel on Microwave Ablation Zone Volumes in Lung: A Porcine StudyRadiology2019Volume: 291Issue: 2pp. 504-510Development of Multispectral Optoacoustic Tomography as a Clinically Translatable Modality for Cancer ImagingRadiology: Imaging Cancer2020Volume: 2Issue: 6High-Intensity Focused Ultrasound for Pain Management in Patients with CancerRadioGraphics2018Volume: 38Issue: 2pp. 603-623Focused Ultrasound Hyperthermia for Targeted Drug Release from Thermosensitive Liposomes: Results from a Phase I TrialRadiology2019Volume: 291Issue: 1pp. 232-238See More RSNA Education Exhibits Diagnostic and Procedural Intraoperative Ultrasound: Technique, Tips, and Tricks for Optimizing ResultsDigital Posters2019Novel Image-Guided Micro-Invasive Percutaneous Treatments of Breast Lesions: Where Do We Stand?Digital Posters2019Five Stages of Artifacts: Denial, Anger, Bargaining, Depression, and AcceptanceDigital Posters2019 RSNA Case Collection Cerebral Air EmboliRSNA Case Collection2021Medial Temporal Lobe EncephaloceleRSNA Case Collection2021Trigeminal schwannomaRSNA Case Collection2020 Vol. 2, No. 3 Metrics Downloaded 156 times Altmetric Score PDF download