Preclinical metrics to predict through-focus visual acuity for pseudophakic patients.

Aixa Alarcon,Kendra Hileman,Henk Weeber,Carmen Canovas,Linda Tsai,Patricia Piers,Robert Rosen

doi:10.1364/boe.7.001877

Abstract

This study compares the clinical through-focus visual acuity (VA) in patients implanted with different intraocular lens (IOL) to optical bench testing of the same IOLs to evaluate the suitability of optical metrics of predicting clinical VA. Modulation transfer function and phase transfer function for different spatial frequencies and US Air Force pictures were measured using an optical bench for two monofocal IOLs, three multifocal IOLs and an extended range of vision IOL. Four preclinical metrics were calculated and compared to the clinical through-focus VA collected in three different clinical studies (243 patients in total). All metrics were well correlated (R2≥0.89) with clinical data and may be suitable for predicting through-focus VA in pseudophakic eyes.

Highlights

The preclinical optical performance of intraocular lenses (IOLs) is currently assessed using modulation transfer function (MTF) values at a single spatial frequency of 25, 50 or 100 cycles per mm (ISO standard 11979-2:2014)
This study compares the clinical through-focus visual acuity (VA) in patients implanted with different intraocular lens (IOL) to optical bench testing of the same IOLs to evaluate the suitability of optical metrics of predicting clinical VA
We propose to define and evaluate different preclinical metrics based on optical-bench data in order to better predict the average binocular through-focus VA provided by different IOLs when implanted in pseudophakic patients

Summary

Introduction

The preclinical optical performance of intraocular lenses (IOLs) is currently assessed using modulation transfer function (MTF) values at a single spatial frequency of 25, 50 or 100 cycles per mm (cpmm) (ISO standard 11979-2:2014). It is known that MTF at single spatial frequency is well correlated with contrast sensitivity measured clinically in pseudophakic patients [15,16]. Visual acuity is clinically measured using optotypes that can be deconstructed into multiple spatial frequencies [17,18,19,20]. It may be advantageous to consider multiple spatial frequencies when evaluating the preclinical optical performance of an IOL design in order to predict the potential visual acuity achievable when an IOL design is implanted in the eye

Methods

Results

Conclusion