Preclinical examination of complex antimicrobial preparation for treating endometritis in cows

Igor S Koba ,Omar Odeh Abdl-Mu’Tee,Elena Novicova,Azamat Shantyz,Nikita Daytlov

doi:10.1051/bioconf/20201700186

Abstract

According to a statistical study an average of 40 % of infertile animals have obstetric and gynecological pathologies. Among obstetric and gynecological pathologies, the most common is an acute postpartum endometritis, which make up from 37.8 to 41 %. Therapy and Pharmacology department of the Kuban State Agrarian University has developed a drug for the cows postpartum endometritis treatment. Conducted preclinical tests prove its harmlessness, as a result of which it belongs to hazard class 4. It should be noted that the biochemical blood parameters of rats in the experiment do not go beyond the reference values. The drug has a pronounced antimicrobial effect. MBC is from 7.8 mg to 31.2 mg while MIC is from 31.2 to 62.5 mg for such strains as S. aureus, E. coli, St. xylosus, Ps. aeruginosa, P. vulgaris. The developed drug does not have an irritating and sensitizing effect and exhibits a regenerative effect. Conducted experiments on the wound healing effect of the drug prove that this drug has a high regenerative effect. The average wound healing area was 20.4 % per day.

Highlights

“The main reasons that reduce the broodstock reproductive rate are postpartum functional and inflammatory diseases of the cattle genital organs that cause symptomatic infertility.” [1]
The causes of gynecological pathology are diverse and in most cases are in complex action
The combination of these and other factors leads to the occurrence of postpartum endometritis in cows, which in turn is one of the main reasons for the dairy cattle reproductive health decrease

Summary

Introduction

“The main reasons that reduce the broodstock reproductive rate are postpartum functional and inflammatory diseases of the cattle genital organs that cause symptomatic infertility.” [1]. The research results indicate that the developed drug has a high antimicrobial activity and a wide spectrum of action, which indicates the feasibility of its use for the postpartum diseases treatment in cows.

Results

Conclusion