Abstract
Ghrelin, an orexigenic peptide synthesized by endocrine cells of the gastric mucosa, plays a major role in inhibiting seizures. However, the underlying mechanism of ghrelin's anticonvulsant action is still unclear. Nowadays, there are considerable evidences showing that ghrelin is implicated in various neurophysiological processes, including learning and memory, neuroprotection, neurogenesis, and inflammatory effects. In this review, we will summarize the effects of ghrelin on epilepsy. It may provide a comprehensive picture of the role of ghrelin in epilepsy.
Highlights
Epilepsy is one of the most common chronic neurological disorders
We present a review to introduce the effects of ghrelin on epilepsy and illuminate ghrelin’s advantage of being a therapeutic target in epilepsy
There is considerable evidence showing that ghrelin is involved in regulation of several other important neurophysiological processes, including neuroprotection, neurotransmission and neurogenesis
Summary
Epilepsy is one of the most common chronic neurological disorders. There are approximately more than seventy million people in the world affected by epilepsy [1, 2]. The similar results are detected in des-acyl ghrelin www.impactjournals.com/oncotarget of urine and saliva, indicating that two different forms have similar regulating effect. Due to the neuroprotective and antiepileptic effects of ghrelin, ghrelin secretion is enhanced during the process of central lesions induced by seizures [19, 44,45,46,47,48]. Des-acyl ghrelin was found to significantly elevate seizure thresholds in C57Bl/6 and wild type mice but not in ghrelin receptor knockout mice.
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