Abstract
The aim of present study was to evaluate the nephroprotective effect of probiotic formulation LOBUN on Cyclosporine A (CsA) induced renal dysfunction in Wistar rats. CsA (20 mg/kg body weight s.c) was administered for 15 days to cause renal dysfunction in Wistar rats. The probiotic formulation LOBUN was administered with the dose of 500 mg/kg body weight (p.o) for twice (TGI) and thrice a day (TGII). The samples were analyzed for the parameters like blood urine nitrogen (BUN), serum creatinine, serum uric acid, total serum protein and urine proteins, urine potassium, urine sodium. The renal functional and histopathological studies revealed that the oral administration of probiotic formulation LOBUN has provided appreciable renoprotection and possibly alleviated the symptoms of Chronic Kidney Disease (CKD) at the dose of 500 mg/kg body weight administered thrice a day and also the results were supported by histopathological findings.
Highlights
Chronic Kidney Disease (CKD) is a potentially fatal health problem with an ever-increasing incidence and prevalence in the under developed and developing countries whose health infrastructure is unable to meet the therapeutic needs of large section of population who are economically deprived to afford the high cost of dialysis and renal transplantation
After treatment with probiotic formulation LOBUN, blood and urine samples were analyzed for the parameters like blood urine nitrogen (BUN), creatinine, uric acid, total serum protein (Table I-IV) and urinary protein, potassium, sodium (Table V-VII) respectively
After treatment with probiotic formulation LOBUN at the dose of 500 mg/kg body weight (twice a day (b.i.d) and thrice a day (t.i.d)), the TGs were showed significant reduction in concentrations of the parameters such as serum BUN, serum creatinine, serum uric acid and significant increase in total serum protein when compared to the control group
Summary
Chronic Kidney Disease (CKD) is a potentially fatal health problem with an ever-increasing incidence and prevalence in the under developed and developing countries whose health infrastructure is unable to meet the therapeutic needs of large section of population who are economically deprived to afford the high cost of dialysis and renal transplantation. Cyclosporine A (CsA) is a calcineurin inhibitor which has remained for many years as a crucial immunosuppressant drug with major therapeutic role in early kidney transplantation in various autoimmune diseases (Maria, Perego, Bellia, 2013). These therapeutic benefits have been limited by the most serious complications like nephrotoxicity and cardiovascular events. CsA nephrotoxicity is associated with imbalanced red-ox state and associated oxidative stress in renal tubular, endothelial and glomerular cells It is accomplished by the development of morphological changes including vascular injury with ischemic damage, afferent arteriolopathy, intestinal fibrosis, progressive glomerular sclerosis, tubular and renal cell apoptosis (Subha Palaneeswar, Nagarajan, Manjula Devi, 2014; Jinhwa, 2010)
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