Abstract
Purpose: The purpose of this study was to evaluate the efficacy of a single intra-articular injection of a hyaluronic acid-CHITLAC®-matrix (HY-CTL matrix), enriched with two different concentrations of triamcinolonacetonide (TA)(RV2 and RV4.5, 2.0 mg/ml and 4.5 mg/ml of triamcinolone acetonide respectively), in comparison with the HY-CTL matrix alone (including the excipients used in the RV2 and RV4.5 formulations), with a commercial and clinically accepted control TA based (KENACORT® 40 mg/ml) and with saline solution (NaCl) in an in vivo model of osteoarthritis (OA) induced by monoiodoacetate (MIA) injection in the rat knee joint.
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