Abstract
All SPIO particles that have so far undergone preclinical or clinical testing are coated with an organic polymer such as dextran (1), carboxydextran (2,3), or polyethylene glycol (4). Polymer coating limits the minimal overall particle size that can be achieved. However, the pharmacokinetic and physical properties resulting from a small particle size appear to offer advantages for MR angiography (1). The present article is based on a project in which a manufacturing procedure for coating iron oxide particles with monomeric material was developed (5,6). This procedure allows for producing so-called very small superparamagnetic iron oxide particles (VSOP). Using this procedure, particles with a citrate coating and an overall particle size of 8 nm were produced (VSOP-C184) in order to develop an iron-oxide-based blood pool contrast medium for MR angiography (7,8). This study presents results of a preclinical in vivo characterization of VSOPC184 in terms of toxicity, pharmacokinetics, and efficacy as a contrast medium for vascular MR imaging. MATERIALS AND METHODS
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