Abstract
Objective: Folate receptor alpha (FolRa) is a cell-surface glycoprotein, highly expressed in ovarian and endometrial adenocarcinoma, and is thus a promising target for cancer therapy using antibody drug conjugates (ADCs). We have employed an E. coli cell-free expression system (XpressCFTM) and site-specific conjugation technology to generate STRO-002, a novel, site-specific, and homogenous FolRa-targeting ADC.
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