Abstract
Background: In very low birth weight (VLBW) infants, little is known about NIA in oxygene 18 (O18) and deuterium (D2) and influence of NIA variations on EE measurement with doubly labelled water (DLW) method. Sujects and methods: During a nutritional balance study, urine samples were collected each day during 3 to 5 days in 13 VLBW infants(post-natal age: 28.0±4.4 days, gestational age: 32.5±1.1 SA, body weight: 1509±124 g) fed human milk (n=5) or preterm formula (n=8). NIA was measured (n=54) with isotope ratio mass spectrometer (Optima®, Fisons). Results: NIA was -3.13±0.83 ∂%o for O18 and-24.56±3.63 ∂%o for D2, which is close to the adults values. The mean coefficient of variation of EE measurement in relation with NIA variations was 1.98±0.78% (0.62 to 2.98%). Conclusion: In VLBW infants the variations in NIA did not significantly influence precision of EE measurement by DLW method.
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