Abstract

Obesity is a multi-factorial disease that is influenced by genetic, epigenetic, and environmental factors. Precision medicine is a practice wherein prevention and treatment strategies take individual variability into account. It involves using a variety of factors including deep phenotyping using clinical, physiological, and behavioral characteristics, ‘omics assays (e.g., genomics, epigenomics, transcriptomics, and microbiomics among others), and environmental factors to devise practices that are individualized to subsets of patients. Precision medicine for obesity has limited data thus far but is an evolving field. Even controlling for follow-up and patient compliance, we see variations in clinical response to bariatric procedures. Personalizing the therapeutic modality to the individual can lead to enhanced effectiveness and tolerability. We review advances in precision medicine made in the field of bariatrics and discuss future avenues and challenges.

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