Abstract
Precision and reproducibility of semi-automated late gadolinium enhancement quantification techniques in patients with hypertrophic cardiomyopathy
Highlights
The presence and extent of hyper-enhancement (HE) on Late Gadolinium Enhancement (LGE) has been associated with adverse events in patients with Hypertrophic Cardiomyopathy (HCM)
The SI threshold applied for each slice and total HE volume were recorded
The Signal Threshold versus Reference Mean (STRM) > 3SD technique provides the greatest precision while retaining acceptable reproducibility and may be the preferred approach for HE quantification in this population
Summary
The presence and extent of hyper-enhancement (HE) on Late Gadolinium Enhancement (LGE) has been associated with adverse events in patients with Hypertrophic Cardiomyopathy (HCM). Signal-threshold techniques are routinely employed for quantification; the precision and reproducibility of these versus a gold standard remains uncertain. Full Width Half of Maximum (FWHM) techniques are suggested to provide greater reproducibility than Signal Threshold versus Reference Mean (STRM) techniques, the precision of these approaches versus manual assignment of optimal signal intensity(SI) thresholds has not been studied. We compare all known semiautomated LGE-quantification techniques for precision and reproducibility among patients with HCM
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