Abstract
The modulation of the recognition site has great potential for the development of high-performance fluorescent sensors, but the regulation of preferential combination between the recognition site and the target molecules has rarely been studied. Here, to boost the response speed of the fluorescent probe, the recognition site is regulated via design of the electron-withdrawing ability of the adjacent R-benzene group. The interaction between the ester bond and hydrazine (N2H4) is precisely modulated to promote effective combination between them in the pre-chemical approach part of the process. The strong electrostatic combination capability, the moderate shielding effect, and the favorable inverse Gibbs free energy barrier together ensure an improved light-up time of 2–3 s for the F-CN probe. The present investigation may facilitate further exploration of fluorescent probes for ultrasensitive and rapid chemical sensing, as well as additional work on interaction modulation for various applications.
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