Abstract
Cyclic PCL (c-PCL) has drawn great attention from academia and industry because of its unique, unusual structure and property characteristics due to the absence of end groups in addition to the biocompatibility and biodegradability of its linear analogue. As a result of much research effort, several synthetic methods have been developed to produce c-PCLs so far. Their chain, morphology and property characteristics were investigated even though carried out on a very limited basis. This feature article reviews the research progress made in the synthesis, morphology, and properties of c-PCL; all results and their pros and cons are discussed in terms of purity and molecular weight distribution in addition to the cyclic topology effect. In addition, we attempted to synthesize a series of c-PCL products of high purity by using intramolecular azido-alkynyl click cyclization chemistry and subsequent precise and controlled separation and purification; and their thermal degradation and phase transitions were investigated in terms of the cyclic topology effect.
Highlights
Linear poly(ε-caprolactone) (PCL) has attracted great attention from both academia and industry because of its wide application potential ranging from surgical sutures, stents, prosthetics, artificial implants, wound dressings, tissue engineering, drug delivery systems, to environmentally friendly material systems, based on its biocompatibility and biodegradability [1,2,3,4,5].The research interest has recently been extended to topological PCLs
We review the synthetic schemes, properties, and morphological structures of cyclic PCL (c-PCL) reported in the literature so far
Polymers 2018, 10, 577 was synthesized by using the intramolecular click chemistry of linear PCL precursors possessing an azido group on one chain end and an alkynyl group on the other chain end; their thermal properties were examined by using thermogravimetry (TGA) and differential scanning calorimetry (DSC)
Summary
Linear poly(ε-caprolactone) (PCL) has attracted great attention from both academia and industry because of its wide application potential ranging from surgical sutures, stents, prosthetics, artificial implants, wound dressings, tissue engineering, drug delivery systems, to environmentally friendly material systems, based on its biocompatibility and biodegradability [1,2,3,4,5]. The properties and structures of c-PCL products have been investigated on a very limited basis. In this feature article, we review the synthetic schemes, properties, and morphological structures of c-PCL reported in the literature so far. We discuss new results of the precise synthesis and thermal properties of c-PCL recently achieved in our laboratory. Polymers 2018, 10, 577 was synthesized by using the intramolecular click chemistry of linear PCL precursors possessing an azido group on one chain end and an alkynyl group on the other chain end; their thermal properties were examined by using thermogravimetry (TGA) and differential scanning calorimetry (DSC)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
