Abstract
AbstractStimulated Raman scattering (SRS) microscopy in combination with innovative tagging strategies offers great potential as a universal high‐throughput biomedical imaging tool. Here, we report rationally tailored small molecular monomers containing triple‐bond units with large Raman scattering cross‐sections, which can be polymerized at the nanoscale for enhancement of SRS contrast with smaller but brighter optical nanotags with artificial fingerprint output. From this, a class of triple‐bond rich polymer nanoparticles (NPs) was engineered by regulating the relative dosages of three chemically different triple‐bond monomers in co‐polymerization. The bonding strategy allowed for 15 spectrally distinguishable triple‐bond combinations. These accurately structured nano molecular aggregates, rather than long‐chain macromolecules, could establish a universal method for generating small‐sized biological SRS imaging tags with high sensitivity for high‐throughput multi‐color biomedical imaging.
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