Precise Controlled Target Molecule Release through Light-Triggered Charge Reversal Bridged Polysilsesquioxane Nanoparticles.

Xin Zhang,Rui Liu,Mengmeng Zhang,Ci Song,Gang Liu,Tongtong Zhao,Linchuan Yang,Mingyue Wu,Rui Zhang,Qingzeng Zhu

doi:10.3390/polym13152392

Abstract

Precise control of target molecule release time, site, and dosage remains a challenge in controlled release systems. We employed a photoresponsive molecule release system via light-triggered charge reversal nanoparticles to achieve a triggered, stepwise, and precise controlled release platform. This release system was based on photocleavage-bridged polysilsesquioxane nanoparticles which acted as nanocarriers of doxorubicin loaded on the surface via electrostatic interaction. The nanoparticles could reverse into positive charges triggered by 254 nm light irradiation due to the photocleavage of the o-nitrobenzyl bridged segment. The charge reversal property of the nanoparticles could release loaded molecules. Doxorubicin was selected as a positively charged model molecule. The as-prepared nanoparticles with an average size of 124 nm had an acceptable doxorubicin loading content up to 12.8%. The surface charge of the nanoparticles could rapidly reverse from negative (−28.20 mV) to positive (+18.9 mV) upon light irradiation for only 10 min. In vitro release experiments showed a cumulative release up to 96% with continuously enhancing irradiation intensity. By regulating irradiation parameters, precisely controlled drug release was carried out. The typical “stepped” profile could be accurately controlled in an on/off irradiation mode. This approach provides an ideal light-triggered molecule release system for location, timing, and dosage. This updated controlled release system, triggered by near-infrared or infrared light, will have greater potential applications in biomedical technology.

Highlights

A controlled molecule release system holds the ability to trigger molecules release and maintain an effective concentration of molecules at the target site
Linyong Zhu groups provided a mesoporous silica nanoparticle grafted by the phototrigger coumarin modified with the drug chlorambucil, which could precisely regulate drug release upon light manipulation [17]
Magnetic silica nanoparticles fabricated using a coumarin-chlorambucil covalent conjugate were used for the precise control of the photolytic release of chlorambucil [18]

Summary

Introduction

A controlled molecule release system holds the ability to trigger molecules release and maintain an effective concentration of molecules at the target site. A direct method for precisely controlling the dosage of drugs is the covalent combination of photocleavable nanocarriers and target molecules [14]. The photocleavage of nanocarriers by light leads to the removal of the drug molecules, giving precise control over the drugs. Yibing Zhao reported that carboxytetramethylrhodamine, as a drug model, could be covalently caged by o-nitrobenzyl linkage-modified silica nanoparticles through a direct esterification process and released precisely by light [16]. Linyong Zhu groups provided a mesoporous silica nanoparticle grafted by the phototrigger coumarin modified with the drug chlorambucil, which could precisely regulate drug release upon light manipulation [17]. Pradeep Singh grouped developed photoresponsive mesoporous silica nanoparticles for the precise controlled release of chlorambucil attached to a quinoline phototrigger covalently [19]. Whereas the covalent method still has nonnegligible defects that the complicated chemical preparation and multistep operation might affect the effective efficiency of molecules, so it is urgent to find a new strategy to overcome the drawback

Methods

Results

Conclusion