Precise Control of Self‐assembly in vivo Based on Polymer‐Peptide Conjugates†

Abstract

Comprehensive SummaryThe self‐assembled nanomaterials based on peptides, which have not only good biocompatibility and low toxicity but also high stability and performance, are increasingly becoming an important way for cancer treatment. In this review, we highlight the progress of in vivo self‐assembled polymer‐peptide conjugates (PPCs) and their application, showing the recent advances in the development of “in vivo self‐assembly” strategy for cancer treatment. Given the diverse microenvironments of tumor cells, different responsive assembly strategies (enzyme, pH, redox, temperature, etc.) have been developed to precisely control the assembly at different biological levels, realizing enhanced drug delivery and improved anticancer efficacy.