Abstract
Quantitative precipitin analyses were made with a macroglobulin fraction of a primary response antiserum to diazobenzidine-BSA. In contrast to the reaction of 7 S anti-BSA the macroglobulin antibody-antigen complexes showed no evidence of solubility in extreme antigen excess. Using labeled antigen, the antibody to antigen ratios were calculated and extrapolated to infinite antigen excess. If a molecular weight of rabbit macroglobulin of 900,000 is assumed, a maximum of five antigen molecules could be bound by a macroglobulin antibody. When a comparison of equal molar concentrations of high and low molecular weight anti-BSA fractions was made by the passive hemagglutination procedure, the macroglobulin was about ten times more active than the 7 S antibody.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
