Abstract
AbstractThe aims of this research were to investigate the applicability of the supercritical anti‐solvent (SAS) process on the precipitation of pharmaceuticals (andrographolide and acetaminophen). In particular, the goal of this research was to study the influence of pressure at 10 and 24 MPa on particle characteristics (morphology, crystalline structure, polymorphic form, size, size distribution, and precipitation yield), and to compare the precipitation efficiency of SAS process and evaporation process. Scanning electron microscope (SEM), X‐ray diffraction (XRD), and high performance liquid chromatography (HPLC) showed a significant change in particle size, size distribution, morphology, and precipitation yield, respectively. From an analysis of the results it was found that the crystal size of andrographolide and acetaminophen decreased with increasing pressure. The morphology of andrographolide particles changed from slice‐like to column‐like when the pressure was increased. On the other hand, the acetaminophen particles obtained were found to be monoclinic form (I) under both operating pressures. The SAS process produced small uniform shaped crystals, with a narrow size distribution, high precipitation yield and selective precipitation were also observed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
