Abstract

Objective To observe the changes in pathology and expression of RAGE (receptor for advanced glycation endproducts) and S100A6 in lung tissue of rats exposed to long-term radon inhalation. Methods Healthy Wistar male rats were exposed to radon in a multifunctional radon chamber 16 h per day for about 27 month at a cumulative dose of up to 650 WLM. Pathological changes were observed and the protein expression of PCNA(proliferating cell nuclear antigen) , RAGE and S100A6 were determined using Western blot. Results In lung tissue of rats exposed to radon, inflammation, emphysema and hyperplasy of alveolar epithelial cells were observed, and expressions of PCNA, RAGE and S100A6 were found to be enhanced(PCNA: 0.0067 ±0.009 in control group, 0.174 ± 0.091 in radon exposed group; RAGE: 0.0041 ± 0.006 in control, and 0.4372±0.291 in radon exposed group;S100A6: 0.069±0.055 in control, and 0.493 ± 0.049 in radon exposed group). Conclusion Long-term radon inhalation may cause pathological changes and precancerous change in lung tissues and up-regulated expressions of RAGE and S100A6 proteins. Key words: Radon; Rat; Lung tissue; Receptor for advanced glycation endproducts; Calcium binding protein A6

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.