Abstract
Despite extensive sequence differences between the modern and ancient genes for β-lactamase enzymes, the encoded 2- to 3-billion-year-old Precambrian ancestral proteins fold into canonical structures, forming active enzymes that degrade various β-lactam antibiotics with efficiencies comparable to those of contemporary enzymes, according to Valeria A. Risso and Jose M. Sanchez-Ruiz from the Universidad de Granada in Spain and their collaborators there and elsewhere.
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