Prebiotic Synergy1 (oligofructose enriched inulin) reduces risk factors for osteoporosis

Abstract

Aim To evaluate potential of dietary Synergy1 to increase bone density in children as a factor to reduce risk for osteoporosis. Methods Two groups of 50 girls and boys (11-14yr) were given 8g/day Synergy1 (oligofructose enriched inulin) or placebo for a period of 1yr in a parallel study design. Ca absorption (To, 2 and 12mo) and bone density (To and 12mo) were measured. Results and discussion Models have shown superior effects with Synergy1 on Ca and Mg absorption. Potential for postponing osteoporosis was further evaluated in growing rats and in ovary-ectomized rats, where bone mineral content increased and ovary-ectomy induced loss of bone structure was impeded. This supported the hypotheses that Synergy1 might increase peak bone mass during adolescence. Stable isotope studies in adolescents (15g/d OF 9d) and in pre-pubertal girls (8g/d Synergy1 3w) found significant increased Ca absorption. Children having lowest calcium absorption at baseline displayed greatest benefit. In elderly women both Ca and Mg absorption improved. Present 1-year intervention confirmed increased Ca absorption with Synergy1 at 2mo. The effect was still there after 12mo. Hence impact on Ca absorption is not temporary. Increased availability of Ca resulted in increased bone density and accretion rate (Abrams 05 AJCN). Conclusion Dietary Synergy1 may be efficient in reducing the risk for osteoporosis through persistently increasing Ca absorption.