Prebiotic intervention improves dyslipidemia and body composition (624.29)

Abstract

A metabolic health crisis is well recognized as cardiovascular diseases remain the leading cause of mortality. Effects of RS4, a prebiotic fiber, in comprehensive management of metabolic syndrome (MetS) remain unknown. This study examined the effects of a blinded exchange of resistant starch type‐4 (RS4)‐enriched flour (30% v/v) with regular/control flour (CF) diet on multiple MetS comorbidities. In a double‐blind, placebo‐controlled, cluster crossover intervention (n=86, age蠅18, 2 12‐week interventions), individuals were classified as having MetS (With‐MetS) or not having MetS (No‐MetS) following IDF criteria. RS4 consumption compared with CF resulted in 7.2% (p=0.002) lower mean total cholesterol (TC), 5.5% (p=0.04) lower non‐HDL, and a 12.8% (p<0.001) lower HDL cholesterol in the With‐MetS group. Individuals in the No‐MetS group had a 2.6% (p=0.02) smaller waist circumference and 1.5% (p=0.03) lower percent body fat following RS4 intervention compared to CF. A small but significant 1% increase in fat‐free mass also was observed in all participants combined (p=0.02). No significant effect of RS4 was observed for glycemic variables and blood pressure. RS4 consumption improved dyslipidemia and body composition. Functional and adaptable prebiotic food ingredients such as RS4 could be an effective strategy for public metabolic and cardiovascular health promotion. NCT01887964 at clinicaltrials.gov.Grant Funding Source: Funding from MGP Ingredients, Atchison KS (# 3P2662), SDAES (#AH360) to MD , EAM to BS