Abstract
Pancreatic islet transplantation (ITx) is a treatment option for restoring glucose balance in some individuals with type 1 diabetes (T1D). However, the need for multiple donors to achieve insulin independence is an obstacle preventing ITx from becoming the standard of care in T1D. Exercise improves insulin sensitivity, increases insulin-independent glucose uptake, shortens recovery from surgery and decreases surgery-related complication risk. We tested the hypothesis that pre-transplant exercise training (RUN, n=7) would improve blood glucose outcomes in an STZ-induced T1D rat model having undergone syngeneic ITx with marginal islet mass (7000 IEQ/kg) compared to similarly-treated sedentary controls (SIT, n=6).
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