Pre-school wheezing: from phenotypes to natural evolution

Abstract

The study aimed to investigate the clinical and immunological characteristics of differentphenotypesofwheezingsyndromeinearly-agechildren.Acontrolled,different phenotypes of wheezing syndrome in early-age children. A controlled, non-randomizedclinicaltrialwasconductedinvolving120childrenwithwheezingnon-randomized clinical trial was conducted involving 120 children with wheezing symptoms,agedbetween5and7years,dividedintotwogroups:patientswithepisod-symptoms, aged between 5 and 7 years, divided into two groups: patients with episod-icwheezingandpatientswithmultifactorialwheezingsyndrome.Thestudyfoundic wheezing and patients with multi factorial wheezing syndrome. The study found that66.7%ofthepatientshadmultifactorialwheezingsyndrome,while33.3%hadthat 66.7% of the patients had multi factorial wheezing syndrome, while 33.3% had episodicwheezing.Childrenwithmultifactorialwheezingsyndromehadahigherepisodic wheezing. Children with multi factorial wheezing syndrome had a higher incidenceofrhinitis,hayfever,andallergicskindamagethanthosewithepisodicincidence of rhinitis, hay fever, and allergic skin damage than those with episodic wheezing.Additionally,72%ofpatientswithmultifactorialwheezingsyndromehadwheezing. Additionally, 72% of patients with multi factorial wheezing syndrome had aheavyhereditaryanamnesis.Allergicreactionswerepresentin98.7%ofpatientsa heavy hereditary anamnesis. Allergic reactions were present in 98.7% of patients withmultifactorialwheezingand77.8%ofchildrenwithepisodicwheezing.Thewith multi factorial wheezing and 77.8% of children with episodic wheezing. The studydidnotobserveanysignificantdifferenceintheageofonsetofthediseasestudy did not observe any signifi cant difference in the age of onset of the disease betweenthetwogroups.Thecausesofdiseaseexacerbationinthemultifactorialbetween the two groups. The causes of disease exacerbation in the multi factorial wheezinggroupweremainlyviralinfectionsandallergens,whileintheepisodicwheezing group were mainly viral infections and allergens, while in the episodic wheezinggroup,theprimarytriggerwasviralinfection.Thestudyconcludedthatwheezing group, the primary trigger was viral infection. The study concluded that evaluatingmultivariateclinicalfeaturesandusingflexiblemathematicalapproachesevaluating multivariate clinical features and using fl exible mathematical approaches arenecessarytoimprovetheclassificationofwheezingphenotypes,whichwouldare necessary to improve the classifi cation of wheezing phenotypes, which would helpinindividualphenotypictherapy.help in individual phenotypic therapy.