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Abstract
UV-pre-resonance Raman spectroscopy (PRS) and surface-enhanced Raman spectroscopy (SERS) were applied to study the interaction of the antiviral and antiparkinsonian agent amantadine with histidine. The binding sites of amantadine and histidine molecules were identified in the complex. In this model, (i) the amino group of amantadine and the N1H group of histidine are included in the complex formation, (ii) the creation of the complex is mediated via formation of an H-bond between the nitrogen of the amantadine amino group and the hydrogen of the histidine N1H group. This model of the amantadine–histidine complex formation is discussed in the relation to a possible mode of interaction of the M2 protein transmembrane region with amantadine.
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