Abstract
Hyperemesis gravidarum is known to be associated with poor perinatal outcomes. This study aimed to identify pre-pregnancy risk factors for hospital admission in women with hyperemesis gravidarum. We enrolled women who had delivered between 1 January 2013 and 31 December 2015, and had undergone a national health screening examination through the National Health Insurance Corporation 1–2 years before their first delivery. Multiple logistic regression analysis was performed to estimate the risk factors for hospital admission due to hyperemesis gravidarum. Of the 216,373 study participants with hyperemesis gravidarum, 2210 (1.02%) pregnant women were hospitalized. These women had lower waist circumference and were underweight based on body mass index compared to pregnant women who did not require hospitalization due to hyperemesis gravidarum. On multivariate analysis, primiparity, multiple pregnancies, female fetus, alcohol consumption, and pre-pregnancy underweight status were associated with an increased risk of hospitalization due to the condition. In this population-based cohort study, we found that hospitalization due to hyperemesis gravidarum was associated with pre-pregnancy lifestyle characteristics. Early recognition and management of these pre-pregnancy factors may help control the need for hospitalization in women with the condition in subsequent pregnancies.
Highlights
Hyperemesis gravidarum (HG) is defined as unrelenting nausea and excessive vomiting initiated before the 22nd week of gestation with or without metabolic disturbances, such as electrolyte imbalances, acid-base imbalances, nutritional deficiencies, ketonuria, and weight loss
We found that low BMI before pregnancy is a risk factor for hospitalization due to HG
The goal of our study was to identify the patients at risk of developing severe HG and those requiring hospitalization during pregnancy
Summary
Hyperemesis gravidarum (HG) is defined as unrelenting nausea and excessive vomiting initiated before the 22nd week of gestation with or without metabolic disturbances, such as electrolyte imbalances, acid-base imbalances, nutritional deficiencies, ketonuria, and weight loss. The incidence of hospitalization for HG is 1–3% among all pregnancies and is the most common cause of hospital admission in the first trimester. HG is known to cause severe perinatal morbidities such as Wernicke’s encephalopathy [1], acute renal failure [2], and fetal growth restriction, preterm birth, and neurodevelopmental delay in the child [3,4]. The symptoms usually cease at the end of the first or early second trimester; could extend throughout pregnancy in approximately one-third of the cases, leading to severe weight loss, malnutrition, and dehydration [5]. Women with a history of prior admission due to HG have a higher probability of subsequent severe HG [6]. Physiological, and emotional support may be necessary in the management of severe HG
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
