Abstract
SummaryFifty primigravid patients at term with ruptured membranes before labour and an unripe cervix were allocated at random to be managed by vaginal prostaglandin E2 tablets or by intravenous oxytocin infusion. With prostaglandin there were longer intervals from treatment to the onset of contractions, to the second stage of labour and to delivery. The incidences of assisted delivery in general and caesarean section in particular were not increased. Two neonates, both from the prostaglandin patients, became pyrexial and were treated with antibiotics, but there were no serious infections in either group. We conclude that there are no advantages to initial treatment with prostaglandin E2 vaginal tablets over the use of an oxytocin infusion.
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