Abstract
BackgroundTrauma-induced coagulopathy is one of the most difficult issues to manage in severely injured patients. The plasma efficacy in treating haemorrhagic-shocked patients is well known. The debated issue is the timing at which it should be administered. Few evidences exist regarding the effects on mortality consequent to the use of plasma alone given in pre-hospital setting. Recently, two randomized trials reported interesting and discordant results. The present paper aims to analyse data from those two randomized trials in order to obtain more univocal results.MethodsA systematic review with meta-analysis of randomized controlled trials (RCTs) of pre-hospital plasma vs. usual care in patients with haemorrhagic shock.ResultsTwo high-quality RCTs have been included with 626 patients (295 in plasma and 331 in usual care arm). Twenty-four-hour mortality seems to be reduced in pre-hospital plasma group (RR = 0.69; 95% CI = 0.48–0.99). Pre-hospital plasma has no significant effect on 1-month mortality (RR = 0.86; 95% CI = 0.68–1.11) as on acute lung injury and on multi-organ failure rates (OR = 1.03; 95% CI = 0.71–1.50, and OR = 1.30; 95% CI = 0.92–1.86, respectively).ConclusionsPre-hospital plasma infusion seems to reduce 24-h mortality in haemorrhagic shock patients. It does not seem to influence 1-month mortality, acute lung injury and multi-organ failure rates.Level of evidence: Level IStudy type: Systematic review with Meta-analysis
Highlights
Trauma-induced coagulopathy is one of the most difficult issues to manage in severely injured patients
The efficacy of plasma in the management of patients suffering from haemorrhagic shock is well known, but timing of its administration is less clear
The present paper aims to summarize data from those two studies in order to obtain more univocal results
Summary
Trauma-induced coagulopathy is one of the most difficult issues to manage in severely injured patients. The present paper aims to analyse data from those two randomized trials in order to obtain more univocal results. Trauma-induced coagulopathy is one of the most difficult issues to deal with in severely injured patients. It leads to uncontrolled bleeding and/or uncontrollable fibrinolysis due to depletion in pro- and anti-coagulant factors. The efficacy of plasma in the management of patients suffering from haemorrhagic shock is well known, but timing of its administration is less clear. The present paper aims to summarize data from those two studies in order to obtain more univocal results
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