Pre-hospital low-volume resuscitation with hemoglobin-glutamer-200 (Hb-200) in a canine hemorrhagic shock model

Abstract

Recently, hypotensive small volume fluid resuscitation has been advocated for early treatment of hemorrhagic shock to avoid aggravating further blood loss and to minimize hemodilution. Our objective was to study whether a hemoglobin-based O2 carrier is more efficacious than crystalloids for pre-hospital treatment of severe hemorrhage. Effects of Hb-200 (Oxyglobin) on systemic hemodynamic and oxygenation functions and on muscle blood flow (MBF), muscle O2 tension (PMO2) and debt (O2DebtM), as well as on systemic lactate levels were studied during the early post-hemorrhage resuscitation period (pre-hospital).